Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Chem Biol Drug Des. 2011 Aug;78(2):229-35. doi: 10.1111/j.1747-0285.2011.01133.x. Epub 2011 Jun 16.
Modification of the ring nucleus of tetramic acids derived from serine gives chiral heterocyclic libraries that exhibit antibacterial activity, and correlation with various physicochemical parameters indicates that chiral tetramic acids may provide a potentially valuable non-aromatic skeleton for fragment-based drug discovery.
对来源于丝氨酸的四氢酸的环核进行修饰，得到具有抗菌活性的手性杂环文库，与各种物理化学参数的相关性表明，手性四氢酸可能为基于片段的药物发现提供一种有潜在价值的非芳香骨架。
