Oleksak Patrik, Gonda Jozef, Nepovimova Eugenie, Kuca Kamil, Musilek Kamil
University of Hradec Kralove, Faculty of Science, Department of Chemistry Rokitanskeho 62 500 03 Hradec Kralove Czech Republic
Pavol Jozef Safarik University, Faculty of Science, Department of Organic Chemistry Moyzesova 11 040 01 Kosice Slovak Republic.
RSC Adv. 2020 Nov 9;10(67):40745-40794. doi: 10.1039/d0ra08396h.
Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura from the sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date.
恶唑霉素A和新恶唑霉素于1985年首次由上村小组从该种细菌中分离出来。迄今为止，已报道了15种不同的天然化合物，它们通常被归类为恶唑霉素家族的一部分。所有恶唑霉素化合物都具有独特的结构，并且它们代表了一个合成挑战。这类分子还因其广泛的生物活性而闻名，包括抗菌、抗病毒和细胞毒性作用。本综述总结了恶唑霉素化合物的结构解析和分类、它们的生物合成及生物活性。它还进一步聚焦于恶唑霉素的全合成以及迄今为止报道的一次形式合成。
