卡介苗预处理后禽肉瘤病毒诱导的肿瘤生长增强。
Enhancement of avian sarcoma virus-induced tumor growth after pretreatment with BCG.
作者信息
Wainberg M A, Israel E
出版信息
Infect Immun. 1978 Nov;22(2):328-33. doi: 10.1128/iai.22.2.328-333.1978.
Pretreatment of chickens with BCG 1 week before inoculation with avian sarcoma virus had a stimulatory effect on virus-induced tumor growth in 15 of 17 cases tested. This outcome was dependent upon the injection of both BCG and the oncogenic agent into the same wing web. Injection of BCG into the wing web contralateral to that used for virus inoculation or injection of a subcellular fraction of BCG into the same wing web did not affect tumor development. Administration of BCG also gave rise to heightened levels of tumor-associated, cell-mediated immunity, both on the part of chickens which received a subsequent injection of oncogenic virus as well as normal, BCG-inoculated controls.
在接种禽肉瘤病毒前1周用卡介苗预处理鸡，在17例测试病例中有15例对病毒诱导的肿瘤生长有刺激作用。这一结果取决于将卡介苗和致癌剂注射到同一翼下。将卡介苗注射到与接种病毒的翼相对的另一侧翼下，或将卡介苗的亚细胞部分注射到同一翼下，均不影响肿瘤的发展。给予卡介苗还会使肿瘤相关的细胞介导免疫水平升高，无论是在随后接种致癌病毒的鸡身上，还是在正常接种卡介苗的对照鸡身上。
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