Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Brain Behav Immun. 2011 Aug;25(6):1264-71. doi: 10.1016/j.bbi.2011.04.017. Epub 2011 Apr 30.
To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD).
Serum BDNF concentrations were assayed by ELISA and fitness was assessed using a standardized exercise stress test. The Mini Mental Status Examination (MMSE), California Verbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.
In subjects with CAD (n=88; 85.2% male, mean age 62.8±10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β=.305, p=.013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1,87)=15.406, p<.0005) and better performance on the Digit Symbol-Coding task (F(1,87)=9.620, p=.003). IL-6, TNF-α and the val66met genotype did not influence these results.
Serum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.
评估血清脑源性神经营养因子（BDNF）浓度作为心肺功能的相关性指标，以及作为冠状动脉疾病（CAD）患者认知表现的预测因子。
通过 ELISA 测定血清 BDNF 浓度，使用标准化运动应激试验评估体能。进行简易精神状态检查（MMSE）、加利福尼亚语言学习测验第二版、斯特鲁普测试、连线测试 B 和数字符号编码任务。确定 val66met BDNF 基因型和血清白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）浓度作为潜在的混杂因素。
在 CAD 患者（n=88；85.2%为男性，平均年龄 62.8±10.5 岁）中，心肺功能与更高的血清 BDNF 浓度相关（β=.305，p=.013）。更高的血清 BDNF 浓度与更高的 MMSE 评分（F(1,87)=15.406，p<.0005）和数字符号编码任务更好的表现相关（F(1,87)=9.620，p=.003）。IL-6、TNF-α和 val66met 基因型并没有影响这些结果。
血清 BDNF 浓度与 CAD 患者的心肺功能、精神运动处理速度和整体认知能力相关。
