Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.
Neuroscience. 2011 Mar 17;177:170-6. doi: 10.1016/j.neuroscience.2011.01.018. Epub 2011 Jan 14.
It is well established that physical exercise can exert neuroprotection both in clinical settings and animal experiments. A series of studies have demonstrated that physical exercise may be a promising preconditioning method to induce brain ischemic tolerance through the promotion of angiogenesis, mediation of the inflammatory response, inhibition of glutamate over-activation, protection of the blood brain barrier (BBB) and inhibition of apoptosis. Through these mechanisms, exercise preconditioning may reduce the neural deficits associated with ischemia and the development of brain infarction and thus provide brain ischemic tolerance. An awareness of the benefits of exercise preconditioning may lead more patients to accept exercise therapy in cases of ischemic stroke.
众所周知，体育锻炼无论是在临床环境还是在动物实验中都能发挥神经保护作用。一系列研究表明，体育锻炼可能是一种很有前途的预处理方法，它可以通过促进血管生成、调节炎症反应、抑制谷氨酸过度激活、保护血脑屏障 (BBB) 和抑制细胞凋亡来诱导脑缺血耐受。通过这些机制，运动预处理可以减少与缺血相关的神经功能缺损和脑梗死的发展，从而提供脑缺血耐受。对运动预处理益处的认识可能会促使更多的缺血性脑卒中患者接受运动治疗。
