tau 的多面性。
The many faces of tau.
机构信息
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
出版信息
Neuron. 2011 May 12;70(3):410-26. doi: 10.1016/j.neuron.2011.04.009.
Abstract
While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
摘要
虽然蛋白 tau 的微管结合能力已经为人所知多年，但 tau 在信号转导和细胞骨架组织中的新功能最近才出现。在这篇综述中，我们强调了这些功能以及 tau 在神经退行性疾病中的潜在作用。我们还讨论了针对 tau 生物学各个方面的药物的治疗潜力。
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