Yamada Y, Yamamoto N, Maeno K, Nishiyama Y
Laboratory of Virology, Nagoya University School of Medicine, Japan.
Arch Virol. 1990;110(1-2):121-7. doi: 10.1007/BF01310708.
Camptothecin (CPT), a specific inhibitor of DNA topoisomerase I, effectively inhibited the replication of herpes simplex virus type 2 (HSV-2). CPT was found to reduce the level of immediate early viral mRNA in a dose-response manner. On the other hand, we could not find any evidence that a novel DNA topoisomerase I was induced in HSV-2-infected cells. Our observations suggest that host cell DNA topoisomerase I is involved in the replication of HSV-2.
喜树碱（CPT）是一种DNA拓扑异构酶I的特异性抑制剂，能有效抑制单纯疱疹病毒2型（HSV - 2）的复制。研究发现，CPT能以剂量依赖的方式降低病毒早期即刻mRNA的水平。另一方面，我们未发现任何证据表明HSV - 2感染细胞中诱导产生了新的DNA拓扑异构酶I。我们的观察结果提示，宿主细胞DNA拓扑异构酶I参与了HSV - 2的复制。
