单纯疱疹病毒 1 型 DNA 复制-病毒和细胞因子的协调调节。
HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors.
机构信息
Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
出版信息
Viruses. 2021 Oct 7;13(10):2015. doi: 10.3390/v13102015.
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection.
DNA 复制是单纯疱疹病毒 1 型 (HSV-1) 生命周期中的一个重要步骤，与细胞 DNA 损伤反应、病毒基因组的修复和重组以及病毒基因转录相协调。HSV-1 编码其自身的 DNA 复制机制，包括一个起始结合蛋白 (UL9)、单链 DNA 结合蛋白 (ICP8)、DNA 聚合酶 (UL30)、持续因子 (UL42) 和一个解旋酶/引发酶复合物 (UL5/UL8/UL52)。此外，HSV-1 还利用辅助病毒和细胞因子的组合来协调病毒 DNA 复制与其他病毒和细胞过程。本文旨在概述病毒和细胞蛋白在 HSV-1 DNA 复制和复制偶联过程中的作用，并强调 HSV-1 如何修饰和适应细胞蛋白以促进有效的感染。
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