Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
Chem Commun (Camb). 2011 Jul 28;47(28):7912-6. doi: 10.1039/c1cc11430a. Epub 2011 May 10.
Asymmetric hydrogenation of olefins is one of the most important reactions for the synthesis of optically active compounds, especially in industry. Chiral iridium catalysts based on P,N ligands have strongly expanded their application range. In contrast to rhodium and ruthenium diphosphine complexes they do not require the presence of a coordinating group near the C=C bond and, therefore, allow highly enantioselective hydrogenations of largely unfunctionalized alkenes.
烯烃的不对称氢化反应是合成手性化合物最重要的反应之一，特别是在工业中。基于 P,N 配体的手性铱催化剂大大扩展了它们的应用范围。与铑和钌二膦配合物相比，它们不需要在 C=C 键附近存在配位基团，因此可以对大量未官能化的烯烃进行高度对映选择性氢化。
