Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Rev Soc Bras Med Trop. 2011 Mar-Apr;44(2):150-6. doi: 10.1590/s0037-86822011005000002. Epub 2011 Mar 18.
Chagas disease (ChD) is a chronic illness related to significant morbidity and mortality that can affect the quality of life (QoL) of infected patients. However, there are few studies regarding QoL in ChD. The objectives of this study are to construct a health-related QoL (HRQoL) profile of ChD patients and compare this with a non-ChD (NChD) group to identify factors associated with the worst HRQoL scores in ChD patients.
HRQoL was investigated in 125 patients with ChD and 21 NChD individuals using the Medical Outcomes Study 36-item Short-Form (SF-36) and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ). Patients were submitted to a standard protocol that included clinical examination, ECG, Holter monitoring, Doppler echocardiogram and autonomic function tests.
HRQoL scores were significantly worse among the ChD group compared to the NChD group in the SF-36 domains of physical functioning and role-emotional and in the MLWHFQ scale. For the ChD group, univariate analysis showed that HRQoL score quartiles were associated with level of education, sex, marital status, use of medication, functional classification and cardiovascular and gastrointestinal symptoms. In the multivariate analysis, female sex, fewer years of education, single status, worst functional classification, presence of cardiovascular and gastrointestinal symptoms, associated illnesses, Doppler echocardiographic abnormalities and ventricular arrhythmia detected during Holter monitoring were predictors of lower HRQoL scores.
ChD patients showed worse HRQoL scores compared to NChD. For the ChD group, sociodemographic and clinical variables were associated with worst scores.
恰加斯病（Chagas 病）是一种与较高发病率和死亡率相关的慢性疾病，可影响感染患者的生活质量（QoL）。然而，关于 Chagas 病患者 QoL 的研究较少。本研究的目的是构建 Chagas 病患者的健康相关 QoL（HRQoL）概况，并将其与非 Chagas 病（NChD）组进行比较，以确定与 Chagas 病患者最差 HRQoL 评分相关的因素。
使用医疗结局研究 36 项简短量表（SF-36）和明尼苏达州心力衰竭生活质量问卷（MLWHFQ）对 125 例 Chagas 病患者和 21 例 NChD 个体进行 HRQoL 调查。患者接受了包括临床检查、心电图、动态心电图监测、多普勒超声心动图和自主神经功能测试的标准方案。
与 NChD 组相比，Chagas 病组在 SF-36 身体功能和角色情感领域以及 MLWHFQ 量表中的 HRQoL 评分明显更差。对于 Chagas 病组，单因素分析显示 HRQoL 评分四分位与教育水平、性别、婚姻状况、用药、功能分类以及心血管和胃肠道症状有关。在多因素分析中，女性、受教育年限较少、单身、功能分类最差、存在心血管和胃肠道症状、合并症、多普勒超声心动图异常以及 Holter 监测中检测到的室性心律失常是 HRQoL 评分较低的预测因素。
与 NChD 相比，Chagas 病患者的 HRQoL 评分更差。对于 Chagas 病组，社会人口统计学和临床变量与最差评分相关。
