Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Diamantina, MG, Brasil.
Universidade Federal de Minas Gerais, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Belo Horizonte, MG, Brasil.
Rev Soc Bras Med Trop. 2022 Mar 14;55:e0657. doi: 10.1590/0037-8682-0657-2021. eCollection 2022.
Chagas disease (CD) is a neglected tropical disease associated with poverty in which patients are surrounded by stigma. These factors can contribute to reducing health-related quality of life (HRQoL). Therefore, a broad discussion of HRQoL in the CD population is required. This study aimed to discuss the main findings of HRQoL in patients with CD, focusing on the association between sociodemographic and lifestyle factors, echocardiographic and functional determinants, and the effect of non-invasive interventions on HRQoL. A literature search of the MEDLINE, Web of Science, CINAHL, Scopus, and LILACS databases was performed with no data or language restrictions. Twenty-two articles were included in this meta-analysis. In general, HRQoL is worse in patients with CD than in healthy individuals, particularly in the presence of cardiovascular and/or gastrointestinal symptoms. Sex, age, functional class, level of physical activity, healthy habits, and medications received could affect HRQoL. Among the echocardiographic and functional determinants, decreased systolic function seems to negatively affect HRQoL. No association with the peak oxygen uptake was observed in the maximal tests. By contrast, well-tolerated field tests with submaximal intensities were associated with HRQoL. Both pharmaceutical care and exercise training have a positive effect on the HRQoL of patients with Chagas cardiomyopathy, and the mental component can be a prognostic marker in this population. In conclusion, assessment of HRQoL can provide important information about the health status of patients with CD, and its use in clinical practice is warranted.
恰加斯病（CD）是一种与贫困相关的被忽视的热带病，患者会因此受到歧视。这些因素可能会降低与健康相关的生活质量（HRQoL）。因此，需要广泛讨论 CD 患者的 HRQoL。本研究旨在讨论 CD 患者 HRQoL 的主要发现，重点关注社会人口统计学和生活方式因素、超声心动图和功能决定因素之间的关联，以及非侵入性干预对 HRQoL 的影响。对 MEDLINE、Web of Science、CINAHL、Scopus 和 LILACS 数据库进行了无数据或语言限制的文献检索。共有 22 篇文章纳入本 meta 分析。一般来说，CD 患者的 HRQoL 比健康个体差，尤其是存在心血管和/或胃肠道症状时。性别、年龄、功能分级、体力活动水平、健康习惯和服用的药物可能会影响 HRQoL。在超声心动图和功能决定因素中，收缩功能下降似乎会对 HRQoL 产生负面影响。最大强度测试中未观察到与峰值摄氧量的相关性。相比之下，耐受良好的亚最大强度现场测试与 HRQoL 相关。药物治疗和运动训练都对 Chagas 心肌病患者的 HRQoL 产生积极影响，并且精神成分可能是该人群的预后标志物。总之，HRQoL 的评估可以提供有关 CD 患者健康状况的重要信息，在临床实践中使用是合理的。
