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蘑菇毒素与癌症(综述)

Mushroom toxins and cancer (review).

作者信息

Toth B

出版信息

Int J Oncol. 1995 Jan;6(1):137-45.

PMID:21556514
Abstract

Significant advances have been made in recent years in cancer research concerning the chemistry and biological action of the various mushroom hydrazines and related chemicals as well as two mushrooms, Agaricus bisporus and Gyromitra esculenta. In addition, there is limited information involving the teratogenic effects of some of these mycotoxins. It is apparent that a series of these chemicals, as well as the feeding of two raw mushrooms, induce many cancers in experimental animals. Even though recent findings in the chemistry field indicate that the baked mushroom might act similarly to the raw mushroom with regard to cancer induction, no such studies to date have been undertaken. Thus far cancer epidemiologists have not initiated any research in revealing the effect of mushroom consumption in humans. The practical, frequent question as to whether to cease the consumption of some of the baked mushrooms cannot be answered until additional critical information becomes available. At present, there is no reason for the public to panic.

摘要

近年来,在癌症研究方面取得了重大进展,涉及各种蘑菇肼及相关化学物质以及两种蘑菇,即双孢蘑菇和鹿花菌的化学性质和生物活性。此外,关于其中一些霉菌毒素的致畸作用的信息有限。显然,这些化学物质中的一系列,以及两种生蘑菇的喂食,会在实验动物中诱发多种癌症。尽管化学领域的最新发现表明,烤制蘑菇在致癌方面可能与生蘑菇有相似作用,但迄今为止尚未进行此类研究。到目前为止,癌症流行病学家尚未开展任何研究来揭示食用蘑菇对人类的影响。在获得更多关键信息之前,关于是否应停止食用某些烤制蘑菇这一实际且常见的问题无法得到解答。目前,公众没有理由恐慌。

相似文献

1
Mushroom toxins and cancer (review).蘑菇毒素与癌症(综述)
Int J Oncol. 1995 Jan;6(1):137-45.
2
Gyromitra esculenta mushroom: a comparative assessment of its carcinogenic potency.鹿花菌:对其致癌潜力的比较评估。
In Vivo. 1994 Nov-Dec;8(6):999-1002.
3
Lack of carcinogenesis by the baked mushroom Agaricus bisporus in mice: different feeding regimen [corrected].烤制双孢蘑菇在小鼠中无致癌性:不同喂养方案[已修正]
In Vivo. 1997 May-Jun;11(3):227-31.
4
[Quantities of agaritine in mushrooms (Agaricus bisporus) and the carcinogenicity of mushroom methanol extracts on the mouse bladder epithelium].[蘑菇(双孢蘑菇)中伞菌氨酸的含量及蘑菇甲醇提取物对小鼠膀胱上皮的致癌性]
Nihon Koshu Eisei Zasshi. 1990 Jun;37(6):400-5.
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Agaricus bisporus: an assessment of its carcinogenic potency.
Mycopathologia. 1993 Nov;124(2):73-7. doi: 10.1007/BF01103105.
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Warning on False or True Morels and Button Mushrooms with Potential Toxicity Linked to Hydrazinic Toxins: An Update.警惕具有潜在毒性的假或真羊肚菌和纽扣菇:与肼类毒素有关的更新。
Toxins (Basel). 2020 Jul 29;12(8):482. doi: 10.3390/toxins12080482.
7
Synthetic and naturally occurring hydrazines as possible cancer causative agents.合成及天然存在的肼类化合物作为潜在的致癌因素。
Cancer Res. 1975 Dec;35(12):3693-7.
8
Cancer induction in mice by feeding the raw false morel mushroom Gyromitra esculenta.通过喂食生的皱盖乌头菌(Gyromitra esculenta)诱导小鼠患癌。
Cancer Res. 1992 Apr 15;52(8):2279-84.
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Agaritine content in processed foods containing the cultivated mushroom (Agaricus bisporus) on the Nordic and the Czech market.北欧和捷克市场上含有栽培蘑菇(双孢蘑菇)的加工食品中的伞菌氨酸含量。
Food Addit Contam. 1999 Oct;16(10):439-46. doi: 10.1080/026520399283830.
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[Poisoning by Geromitra esculenta].[食用毒鹅膏中毒]
J Toxicol Clin Exp. 1989 Mar-Apr;9(2):83-99.

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Mushroom Poisoning Mimicking Painless Progressive Jaundice: A Case Report with Review of the Literature.酷似无痛性进行性黄疸的蘑菇中毒:1例报告并文献复习
Cureus. 2018 Apr 5;10(4):e2436. doi: 10.7759/cureus.2436.
2
Stimulation of erythrocyte cell membrane scrambling by mushroom tyrosinase.蘑菇酪氨酸酶对红细胞细胞膜的搅拌作用。
Toxins (Basel). 2014 Mar 18;6(3):1096-108. doi: 10.3390/toxins6031096.
3
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.
姬松茸(巴西蘑菇)不会改变大鼠经二乙基亚硝胺启动的肝前体瘤灶的发展。
Cancer Sci. 2003 Feb;94(2):188-92. doi: 10.1111/j.1349-7006.2003.tb01417.x.