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肿瘤进展过程中需要对转化生长因子-β诱导的转化细胞清除产生抗性（综述-假说）。

Resistance to tgf-Beta-induced elimination of transformed-cells is required during tumor progression (review-hypothesis).

作者信息

Bauer G

出版信息

Int J Oncol. 1995 Jun;6(6):1227-9. doi: 10.3892/ijo.6.6.1227.

DOI:10.3892/ijo.6.6.1227
PMID:21556661
Abstract

We present data that extend the present models of transformation and tumor cell progression by one essential step. In vitro, cocultivation of transformed and normal fibroblasts in the presence of TGF-beta leads to the specific elimination of transformed cells due to induction of apoptosis. This mechanism may represent an effective control step early in carcinogenesis. We propose that in vivo, this control mechanism eliminates arising transformed cells unless certain chemicals interfere with this process or the transformed cells have acquired resistance against it. Acquisition of resistance may be an essential requirement for tumor progression.

摘要

我们展示的数据通过一个关键步骤扩展了目前的细胞转化和肿瘤细胞进展模型。在体外，在转化生长因子-β（TGF-β）存在的情况下，将转化的成纤维细胞与正常成纤维细胞共培养，会因诱导细胞凋亡而导致转化细胞被特异性清除。这种机制可能代表了癌变早期的一个有效控制步骤。我们提出，在体内，除非某些化学物质干扰这一过程或转化细胞获得了对其的抗性，否则这种控制机制会清除新出现的转化细胞。获得抗性可能是肿瘤进展的一个基本条件。

相似文献

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Resistance to tgf-Beta-induced elimination of transformed-cells is required during tumor progression (review-hypothesis).肿瘤进展过程中需要对转化生长因子-β诱导的转化细胞清除产生抗性（综述-假说）。
Int J Oncol. 1995 Jun;6(6):1227-9. doi: 10.3892/ijo.6.6.1227.
2
Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis.正常细胞对转化细胞的清除：癌症发生控制的新概念。
Histol Histopathol. 1996 Jan;11(1):237-55.
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Fibroblasts transformed by chemical carcinogens are sensitive to intercellular induction of apoptosis: implications for the control of oncogenesis.化学致癌物转化的成纤维细胞对细胞间诱导的凋亡敏感：对肿瘤发生控制的启示。
Carcinogenesis. 1997 Feb;18(2):259-64. doi: 10.1093/carcin/18.2.259.
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Catechol interferes with TGF-beta-induced elimination of transformed cells by normal cells: implications for the survival of transformed cells during carcinogenesis.儿茶酚干扰正常细胞对转化生长因子-β诱导的转化细胞的清除：对致癌过程中转化细胞存活的影响。
Int J Cancer. 1995 Feb 8;60(4):520-6. doi: 10.1002/ijc.2910600416.
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Transforming growth factor beta-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis.转化生长因子β处理的正常成纤维细胞通过诱导凋亡消除转化的成纤维细胞。
Cancer Res. 1994 Jan 15;54(2):393-8.
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Three distinct roles for TGF-beta during intercellular induction of apoptosis: a review.转化生长因子-β在细胞间凋亡诱导过程中的三种不同作用：综述
Anticancer Res. 1999 Jan-Feb;19(1A):105-11.
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Clonal analysis of the effect of TGF-beta on the apoptosis-inducing activity of normal cells.转化生长因子-β对正常细胞凋亡诱导活性影响的克隆分析
Exp Cell Res. 1995 May;218(1):71-8. doi: 10.1006/excr.1995.1132.
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Tgf-Beta-induced apoptosis of transformed fibroblasts by normal fibroblasts - independence of cell-to-cell contact and dependence on reactive oxygen species.正常成纤维细胞诱导转化纤维母细胞的 TGF-β 凋亡——不依赖细胞间接触，依赖于活性氧。
Int J Oncol. 1994 Sep;5(3):525-31. doi: 10.3892/ijo.5.3.525.
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Reactive oxygen species act at both TGF-beta-dependent and -independent steps during induction of apoptosis of transformed cells by normal cells.在正常细胞诱导转化细胞凋亡的过程中，活性氧在依赖转化生长因子-β和不依赖转化生长因子-β的阶段均发挥作用。
Exp Cell Res. 1996 Jan 10;222(1):117-24. doi: 10.1006/excr.1996.0015.
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Effect of transforming growth factor beta on rat hepatocyte cell lines depends upon the state of tumorigenic progression.转化生长因子β对大鼠肝细胞系的影响取决于致瘤进展状态。
Cell Growth Differ. 1996 Apr;7(4):449-60.

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