Allen P S
Department of Applied Sciences in Medicine, University of Alberta, Edmonton.
Can Assoc Radiol J. 1990 Feb;41(1):39-44.
The author describes the medical diagnostic and research context into which in vivo nuclear magnetic resonance (NMR) spectroscopy promises to fit. The different constraints and possibilities of in vivo NMR are contrasted with those of conventional in vitro NMR spectroscopy. To illustrate the discussion, examples are given of the roles that phosphorus-31 spectroscopy plays in the evaluation of energy metabolism, that the editing of proton (1H) spectra plays in the observation of individual metabolites such as lactate, and that natural-abundance carbon-13 spectroscopy might play in the investigation of fat metabolism.
作者描述了活体核磁共振(NMR)光谱有望适用的医学诊断和研究背景。将活体NMR的不同限制和可能性与传统体外NMR光谱的限制和可能性进行了对比。为说明讨论内容,列举了磷-31光谱在能量代谢评估中的作用、质子(1H)光谱编辑在观察乳酸等单个代谢物中的作用,以及天然丰度碳-13光谱在脂肪代谢研究中可能发挥的作用等例子。