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腹腔镜与开腹乙状结肠切除术治疗憩室炎:前瞻性随机试验的长期结果。

Laparoscopic versus open sigmoid resection for diverticulitis: long-term results of a prospective, randomized trial.

机构信息

Department of Surgery, Geneva University Hospital and Medical School, Geneva, Switzerland.

出版信息

Surg Endosc. 2011 Oct;25(10):3373-8. doi: 10.1007/s00464-011-1728-8. Epub 2011 May 10.

Abstract

BACKGROUND

Elective laparoscopic sigmoid resection for diverticulitis has proven short-term benefits, but little data are available from prospective randomized trials regarding long-term outcome, quality of life, and functional results.

METHODS

Of 113 patients randomized to undergo laparoscopic (LAP) versus open (OP) sigmoid resection for diverticulitis, 105 (93%, LAP = 54, OP = 51) patients were examined and answered the Gastrointestinal Quality of Life Index (GIQLI) questionnaire, with a median follow-up of 30 (range, 9-63) months after surgery.

RESULTS

Incisional hernias were detected in five (9.8%) patients in the OP group versus seven (12.9%) in the LAP group, P = 0.84). Overall satisfaction with the operation on a scale of 0 (very poor) to 10 (excellent) was 9 (range, 2-10) in the OP group versus 9 (range, 2-10) in the LAP group (P = 0.78). Median GIQLI score was 115 (range, 57-144) in the OP group versus 110 (range, 61-134) in the LAP group (P = 0.17). Overall satisfaction with the cosmetic aspect of the scar on a scale of 0 (very poor) to 10 (excellent) was 8 (range, 1-10) in the OP group versus 9 (range, 0-10) in the LAP group (P = 0.01). Finally, median hospital cost (including reoperations for hernias) was 11,606 (5,230-147,982) CHF in the LAP group versus 12,138 (6,098-39,786) CHF in the OP group (P = 0.47).

CONCLUSIONS

Both open and laparoscopic approaches for sigmoid resection achieve good long-term results in terms of gastrointestinal function, quality of life, and patients' satisfaction. Significant long-term benefits of laparoscopic surgery are restricted to cosmetic (ClinicalTrials.gov protocol #NCT00453830).

摘要

背景

择期腹腔镜乙状结肠切除术治疗憩室炎已被证明具有短期益处,但关于长期结果、生活质量和功能结果,前瞻性随机试验的数据很少。

方法

在 113 例随机接受腹腔镜 (LAP) 与开腹 (OP) 乙状结肠切除术治疗憩室炎的患者中,有 105 例 (93%,LAP=54 例,OP=51 例) 接受了检查并回答了胃肠道生活质量指数 (GIQLI) 问卷,术后中位随访 30 个月 (范围 9-63 个月)。

结果

OP 组有 5 例 (9.8%) 和 LAP 组有 7 例 (12.9%) 患者发生切口疝,P=0.84)。OP 组手术总体满意度评分为 0 (极差) 至 10 (极好) 的 9 例 (范围 2-10),LAP 组为 9 例 (范围 2-10),P=0.78)。OP 组 GIQLI 评分中位数为 115(范围 57-144),LAP 组为 110(范围 61-134),P=0.17)。OP 组对疤痕美容外观的总体满意度评分为 0 (极差) 至 10 (极好) 的 8 例 (范围 1-10),LAP 组为 9 例 (范围 0-10),P=0.01)。最后,LAP 组的中位住院费用(包括疝修补术的再次手术)为 11606 瑞士法郎(5230-147982 瑞士法郎),OP 组为 12138 瑞士法郎(6098-39786 瑞士法郎),P=0.47)。

结论

腹腔镜和开腹乙状结肠切除术在胃肠功能、生活质量和患者满意度方面均取得了良好的长期效果。腹腔镜手术的显著长期益处仅限于美容方面(ClinicalTrials.gov 方案 #NCT00453830)。

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