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早期择期与择期乙状结肠切除术治疗憩室病:不仅时机重要——单中心回顾性分析 133 例患者。

Early elective versus elective sigmoid resection in diverticular disease: not only timing matters-a single institutional retrospective review of 133 patients.

机构信息

Department of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstr. 5, Bldg. 12.46, 40225, Duesseldorf, Germany.

出版信息

Langenbecks Arch Surg. 2022 Jun;407(4):1613-1623. doi: 10.1007/s00423-022-02464-1. Epub 2022 Feb 22.

DOI:10.1007/s00423-022-02464-1
PMID:35194650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9283160/
Abstract

PURPOSE

The optimal timing of elective surgery in patients with the colonic diverticular disease remains controversial. We aimed to analyze the timing of sigmoidectomy in patients with diverticular disease and its influence on postoperative course with respect to the classification of diverticular disease (CDD).

METHODS

Patients who underwent elective laparoscopic sigmoidectomy were retrospectively enrolled and subdivided into two groups based on the time interval between the last attack and surgery: group A, early elective (≤ 6 weeks), and group B, elective (> 6 weeks). Multivariate regression models were used to identify factors which predict conversion to laparotomy, postoperative course, and length of hospital stay.

RESULTS

A total of 133 patients (group A (n = 88), group B (n = 45)) were included. Basic demographic data did not differ between groups except for a higher rate of diabetes in group B (p = 0.009). The conversion rate was significantly higher in group A in comparison to group B (group A vs. group B: n = 23 (26.1%) vs. n = 3 (6.7%), p = 0.007). Logistic regression analysis revealed the timing of surgery and CDD stage as significant predictors for intraoperative conversion. Moreover, the postoperative course was influenced by high age as well as intraoperative conversion and length of hospital stay by conversion, preoperative CRP levels, and elective surgery.

CONCLUSIONS

Both, timing of surgery and the disease stage, influence the conversion rates in laparoscopic sigmoidectomy for diverticular disease. Accordingly, patients with complicated acute or chronic sigmoid diverticulitis should be operated in the inflammation-free interval.

摘要

目的

择期手术治疗结肠憩室病的最佳时机仍存在争议。本研究旨在分析憩室病患者行乙状结肠切除术的时机,并根据憩室病(CDD)的分类评估其对术后病程的影响。

方法

回顾性纳入接受择期腹腔镜乙状结肠切除术的患者,并根据末次发作与手术之间的时间间隔将其分为两组:A 组(≤6 周)和 B 组(>6 周)。采用多变量回归模型来确定预测中转开腹、术后病程和住院时间的因素。

结果

共纳入 133 例患者(A 组 88 例,B 组 45 例)。两组患者的基本人口统计学数据无差异,仅 B 组糖尿病发生率较高(p=0.009)。与 B 组相比,A 组中转开腹率显著更高(A 组 vs. B 组:n=23 [26.1%] vs. n=3 [6.7%],p=0.007)。Logistic 回归分析显示手术时机和 CDD 分期是术中中转的显著预测因素。此外,高龄以及术中中转与术后病程相关,而住院时间与中转、术前 CRP 水平和择期手术相关。

结论

手术时机和疾病分期均影响腹腔镜乙状结肠切除术治疗憩室病的中转率。因此,伴有复杂急性或慢性乙状结肠憩室炎的患者应在炎症缓解期进行手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fd/9283160/a8415d0fe06e/423_2022_2464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fd/9283160/3bb970d02cb5/423_2022_2464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fd/9283160/a8415d0fe06e/423_2022_2464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fd/9283160/3bb970d02cb5/423_2022_2464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fd/9283160/a8415d0fe06e/423_2022_2464_Fig2_HTML.jpg

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