菌毛操纵子对鼠伤寒沙门氏菌附着和侵袭上皮细胞系的作用。
Contribution of fimbrial operons to attachment to and invasion of epithelial cell lines by Salmonella typhimurium.
作者信息
Bäumler A J, Tsolis R M, Heffron F
机构信息
Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201-3098, USA.
出版信息
Infect Immun. 1996 May;64(5):1862-5. doi: 10.1128/iai.64.5.1862-1865.1996.
Abstract
The role of the Salmonella typhimurium fimbrial operons, lpf, fim, and pef, in adhesion to and invasion of epithelial cell lines was investigated. An S. typhimurium lpfC mutant was unable to adhere to or to invade HEp-2 cells, while an S. typhimurium fim deletion mutant did not attach to or enter HeLa cells. These results suggest that adhesion is a prerequisite for invasion and that distinct fimbrial adhesins select different target cells for invasion by S. typhimurium.
摘要
研究了鼠伤寒沙门氏菌菌毛操纵子lpf、fim和pef在上皮细胞系黏附和侵袭中的作用。鼠伤寒沙门氏菌lpfC突变体无法黏附或侵袭HEp-2细胞，而鼠伤寒沙门氏菌fim缺失突变体不能黏附或进入HeLa细胞。这些结果表明黏附是侵袭的先决条件，并且不同的菌毛黏附素为鼠伤寒沙门氏菌选择不同的靶细胞进行侵袭。
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本文引用的文献
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The pef fimbrial operon of Salmonella typhimurium mediates adhesion to murine small intestine and is necessary for fluid accumulation in the infant mouse.鼠伤寒沙门氏菌的菌毛操纵子介导对小鼠小肠的黏附，并且是幼鼠体内液体蓄积所必需的。
Infect Immun. 1996 Jan;64(1):61-8. doi: 10.1128/iai.64.1.61-68.1996.
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The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches.lpf菌毛操纵子介导鼠伤寒沙门氏菌与小鼠派伊尔结的黏附。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):279-83. doi: 10.1073/pnas.93.1.279.
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Signal transduction in the mammalian cell during bacterial attachment and entry.细菌附着和进入过程中哺乳动物细胞内的信号转导。
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Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.同源基因簇控制鼠伤寒沙门氏菌和福氏志贺氏菌对宿主上皮细胞的侵袭。
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A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells.一个受PhoP抑制的基因促进鼠伤寒沙门氏菌对上皮细胞的侵袭。
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Effects of multiplicity of infection, bacterial protein synthesis, and growth phase on adhesion to and invasion of human cell lines by Salmonella typhimurium.多重感染、细菌蛋白质合成及生长阶段对鼠伤寒沙门氏菌黏附及侵入人细胞系的影响。
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Nucleotide sequence of a 13.9 kb segment of the 90 kb virulence plasmid of Salmonella typhimurium: the presence of fimbrial biosynthetic genes.鼠伤寒沙门氏菌90kb毒力质粒13.9kb片段的核苷酸序列：菌毛生物合成基因的存在
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Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization.鼠伤寒沙门氏菌内化所需氧调节基因的鉴定与表征
Infect Immun. 1994 Sep;62(9):3745-52. doi: 10.1128/iai.62.9.3745-3752.1994.
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Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.鼠伤寒沙门氏菌通过穿透并破坏派尔集合淋巴结的特化上皮M细胞引发小鼠感染。
J Exp Med. 1994 Jul 1;180(1):15-23. doi: 10.1084/jem.180.1.15.
10
Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster.鼠伤寒沙门氏菌中乙醇胺的利用：cchA、cchB、eutE、eutJ、eutG、eutH基因簇的核苷酸序列、蛋白质表达及突变分析
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