Johansson M, Karauzum S, Dietrich C, Mandahl N, Hambraeus G, Johansson L, Clausen P, Mitelman F, Heim S
UNIV LUND HOSP,DEPT CLIN PATHOL,S-22185 LUND,SWEDEN. ODENSE UNIV HOSP,DEPT PATHOL,DK-5000 ODENSE,DENMARK. UNIV LUND HOSP,DEPT THORAC SURG,S-22185 LUND,SWEDEN. ODENSE UNIV,DEPT MED GENET,DK-5230 ODENSE,DENMARK.
Int J Oncol. 1994 Jul;5(1):17-26. doi: 10.3892/ijo.5.1.17.
Cytogenetic analysis of 114 adenocarcinomas of the lung revealed clonal abnormalities in 67 tumors. The chromosome numbers ranged from near-diploid to hypertetraploid. Clonal abnormalities seen as the sole anomaly were loss of the Y chromosome (21 tumors), trisomy 7 (2 tumors), and trisomy 12 (1 tumor). A supernumerary ring chromosome was the only clonal change in 4 tumors. The bands most often affected were 17p11-13 (13 cases), 1q10-12 and 1p22 (10 cases each), 1p11-13 and 1q21 (9 cases each), and 11p11, 11p15 and 15p11-13 (6 cases each). The chromosomes most frequently involved in structural rearrangements were chromosomes 1 (30 cases), 11 (20 cases), 3 (17 cases), 17 and 7 (16 cases each). Repeated loss of material from chromosome arms 1p, 3p, 6q, 11p, and 17p and gains of 1q were found. Recurrent structural changes were del(1)(p22) and i(5)(p10) (5 cases each) i(1)(q10), i(13)(q10), i(14)(q10) and del(17)(p11) (3 cases each). We found no abnormalities that seemed to be specifically associated with pulmonary adenocarcinomas, but isochromosomes i(1)(q10), i(5)(p10) and i(13)(q10) and changes of 6q were present in our series at frequencies higher than those generally seen in the other main types of lung cancer.
对114例肺腺癌进行细胞遗传学分析，发现67例肿瘤存在克隆性异常。染色体数目从近二倍体到超四倍体不等。仅作为唯一异常出现的克隆性异常为Y染色体缺失（21例肿瘤）、三体7（2例肿瘤）和三体12（1例肿瘤）。4例肿瘤中唯一的克隆性改变是额外的环状染色体。最常受累的带区为17p11 - 13（13例）、1q10 - 12和1p22（各10例）、1p11 - 13和1q21（各9例）以及11p11、11p15和15p11 - 13（各6例）。结构重排中最常涉及的染色体是1号染色体（30例）、11号染色体（20例）、3号染色体（17例）、17号和7号染色体（各16例）。发现1p、3p、6q、11p和17p染色体臂物质的反复缺失以及1q的增加。复发性结构改变为del(1)(p22)和i(5)(p10)（各5例）、i(1)(q10)、i(13)(q10)、i(14)(q10)和del(17)(p11)（各3例）。我们未发现似乎与肺腺癌特异性相关的异常，但在我们的系列研究中，等臂染色体i(1)(q10)、i(5)(p10)和i(13)(q10)以及6q的改变出现频率高于其他主要类型肺癌中通常所见的频率。
