PHARMACIA ONCOL IMMUNOL,S-22363 LUND,SWEDEN. LUND UNIV,DEPT PHARMACOL,LUND,SWEDEN.
Int J Oncol. 1994 Sep;5(3):627-31. doi: 10.3892/ijo.5.3.627.
Peripheral benzodiazepine receptor (PBZr) binding sites in isolated mitochondrial (m-fractions) and microsomal fractions (p-fractions) from androgen sensitive R-3327 Dunning G and H tumors were studied. Binding in both m- and p-fractions of these tumors was specific, saturable, and of high affinity. A very high density of PBZr was found in m-fraction from both types of tumors. In p-fractions the receptor density was 4- and 7-fold lower than m-fractions from G and H tumors respectively. Receptor densities in both m- and p-fractions from the poorly differentiated fast growing G turner was significantly higher than in the corresponding fractions from the well differentiated slow growing H tumor. These data suggest that in the androgen sensitive prostatic tumors the density of PBZr may be influenced by the growth rate and degree of differentiation.
外周苯二氮䓬受体（PBZr）结合位点在分离的线粒体（m 部分）和微粒体部分（p 部分）从雄激素敏感的 R-3327 Dunning G 和 H 肿瘤中被研究。在这两种肿瘤的 m 部分和 p 部分中，结合是特异性的，饱和的，具有高亲和力。在两种类型的肿瘤的 m 部分中发现了非常高密度的 PBZr。在 p 部分中，受体密度分别比 G 和 H 肿瘤的 m 部分低 4 倍和 7 倍。在分化不良的快速生长的 G 特纳中，m 部分和 p 部分的受体密度均明显高于分化良好的缓慢生长的 H 肿瘤的相应部分。这些数据表明，在外周敏感的前列腺肿瘤中，PBZr 的密度可能受到生长速度和分化程度的影响。
