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帕金森病伴发的抑郁。

Depression in Parkinson's disease.

机构信息

Department of Neurology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.

出版信息

J Neurol. 2011 May;258(Suppl 2):S336-8. doi: 10.1007/s00415-011-6048-3.

DOI:10.1007/s00415-011-6048-3
PMID:21560065
Abstract

Among the recently well appreciated non-motor symptoms in Parkinson's disease (PD), depression plays a prominent role due to its frequency and impact on quality of life. However, depression may be confounded by motor symptoms, especially akinesia and other non-motor symptoms such as apathy, anxiety and dementia. Data on specific diagnostic tools or treatment for depressive symptoms in PD patients are still sparse. Here we summarize an expert opinion based on available data and clinical experience.

摘要

在帕金森病(PD)最近受到广泛关注的非运动症状中,抑郁症因其频率和对生活质量的影响而显得尤为突出。然而,抑郁症可能会受到运动症状的影响,特别是运动不能和其他非运动症状,如冷漠、焦虑和痴呆。关于 PD 患者抑郁症状的具体诊断工具或治疗的数据仍然很少。在这里,我们根据现有数据和临床经验总结了专家意见。

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Depression in Parkinson's disease.帕金森病伴发的抑郁。
J Neurol. 2011 May;258(Suppl 2):S336-8. doi: 10.1007/s00415-011-6048-3.
2
[Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis].[帕金森病中的抑郁。第1部分:流行病学、体征与症状、病理生理学及诊断]
Fortschr Neurol Psychiatr. 2008 Dec;76(12):715-24. doi: 10.1055/s-2008-1038293. Epub 2008 Nov 14.
3
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4
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Depression and Parkinson's disease: current knowledge.抑郁与帕金森病:当前的认识。
Curr Neurol Neurosci Rep. 2013 Dec;13(12):409. doi: 10.1007/s11910-013-0409-5.
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Depression and Parkinson's disease.抑郁症与帕金森病。
J Neurol. 2004 Sep;251 Suppl 6:VI/24-7. doi: 10.1007/s00415-004-1606-6.
7
[Non-motor symptoms in Parkinson's disease: cognition and behavior].帕金森病的非运动症状:认知与行为
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本文引用的文献

1
Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter.新诊断帕金森病中 5-羟色胺转运体结合保留:与多巴胺转运体呈负相关。
J Neurol. 2011 Jan;258(1):19-26. doi: 10.1007/s00415-010-5666-5. Epub 2010 Jul 21.
2
Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial.普拉克索治疗帕金森病患者抑郁症状的随机、双盲、安慰剂对照试验。
Lancet Neurol. 2010 Jun;9(6):573-80. doi: 10.1016/S1474-4422(10)70106-X. Epub 2010 May 7.
3
Suicidal ideation in Parkinson's disease.
Telemonitoring Parkinson's disease using machine learning by combining tremor and voice analysis.
通过结合震颤和语音分析,利用机器学习对帕金森病进行远程监测。
Brain Inform. 2020 Oct 22;7(1):12. doi: 10.1186/s40708-020-00113-1.
4
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study.帕金森病伴发抑郁的微观结构白质特征:一项扩散张量成像重复研究
Front Neurol. 2019 Aug 13;10:884. doi: 10.3389/fneur.2019.00884. eCollection 2019.
5
A Classification System for Assessment and Home Monitoring of Tremor in Patients with Parkinson's Disease.帕金森病患者震颤评估及家庭监测的分类系统
J Med Signals Sens. 2018 Apr-Jun;8(2):65-72.
6
Alteration of Brain Functional Networks in Early-Stage Parkinson's Disease: A Resting-State fMRI Study.早期帕金森病脑功能网络的改变:一项静息态功能磁共振成像研究
PLoS One. 2015 Oct 30;10(10):e0141815. doi: 10.1371/journal.pone.0141815. eCollection 2015.
7
The aqueous extract of Albizia adianthifolia leaves attenuates 6-hydroxydopamine-induced anxiety, depression and oxidative stress in rat amygdala.合欢树叶水提取物可减轻6-羟基多巴胺诱导的大鼠杏仁核焦虑、抑郁和氧化应激。
BMC Complement Altern Med. 2015 Oct 19;15:374. doi: 10.1186/s12906-015-0912-0.
8
The heterogeneity of non-motor symptoms of Parkinson's disease.帕金森病非运动症状的异质性。
Neurol Sci. 2015 Apr;36(4):577-84. doi: 10.1007/s10072-014-1993-0. Epub 2014 Nov 7.
9
Effects of sleep disorders on the non-motor symptoms of Parkinson disease.睡眠障碍对帕金森病非运动症状的影响。
J Clin Sleep Med. 2013 Nov 15;9(11):1119-29. doi: 10.5664/jcsm.3148.
10
Depressive syndromes in neurological disorders.神经障碍中的抑郁综合征。
Eur Arch Psychiatry Clin Neurosci. 2013 Nov;263 Suppl 2:S123-36. doi: 10.1007/s00406-013-0448-6.
帕金森病中的自杀观念
CNS Spectr. 2009 Aug;14(8):431-6. doi: 10.1017/s109285290002040x.
4
Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease.帕金森病中α4β2* -烟碱型乙酰胆碱受体结合减少及其与轻度认知和抑郁症状的关系。
Arch Gen Psychiatry. 2009 Aug;66(8):866-77. doi: 10.1001/archgenpsychiatry.2009.106.
5
A controlled trial of antidepressants in patients with Parkinson disease and depression.帕金森病伴抑郁症患者使用抗抑郁药的对照试验。
Neurology. 2009 Mar 10;72(10):886-92. doi: 10.1212/01.wnl.0000336340.89821.b3. Epub 2008 Dec 17.
6
[Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis].[帕金森病中的抑郁。第1部分:流行病学、体征与症状、病理生理学及诊断]
Fortschr Neurol Psychiatr. 2008 Dec;76(12):715-24. doi: 10.1055/s-2008-1038293. Epub 2008 Nov 14.
7
Depressive symptoms in Parkinson's disease.帕金森病中的抑郁症状
Eur J Neurol. 2008 Apr;15 Suppl 1:21-5. doi: 10.1111/j.1468-1331.2008.02058.x.
8
Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.去甲丙咪嗪与西酞普兰治疗帕金森病伴发抑郁的比较:一项双盲、随机、安慰剂对照研究。
Mov Disord. 2008 Apr 30;23(6):850-7. doi: 10.1002/mds.21966.
9
A validation study of depressive syndromes in Parkinson's disease.帕金森病抑郁综合征的验证研究。
Mov Disord. 2008 Mar 15;23(4):538-46. doi: 10.1002/mds.21866.
10
Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group.帕金森病抑郁的临时诊断标准:美国国立神经疾病与中风研究所/美国国立精神卫生研究所工作组报告
Mov Disord. 2006 Feb;21(2):148-58. doi: 10.1002/mds.20723.