Wåhlen K, Sjölin E, Löfgren P
Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Exp Clin Endocrinol Diabetes. 2011 May;119(5):291-4. doi: 10.1055/s-0031-1273738. Epub 2011 May 10.
Earlier studies suggest that fat mass is the only important factor predicting the circulating leptin level in humans. In this population based cross sectional study on 447 women and 158 men total fasting plasma leptin was related to adipose tissue mass and fat cell size to investigate the importance of adipose tissue cellularity. An abdominal subcutaneous fat biopsy was obtained and mean fat cell volume and mean fat cell weight and size were determined. Fasting serum Leptin and Leptin secretion in vitro was also measured. Body fat mass was measured by bioimpedance. Adipose tissue mass and fat cell size independently associated with leptin levels. Partial correlation coefficients were 0.6 (p<0.001) and 0.3 (p<0.01) for fat mass and fat cell size, respectively. Together they explained 2/3 of leptin variance (i. e., adjusted r (2)). Fat mass was a stronger regressor than fat cell volume. The relationship was independent of age, gender and adipocyte secretion of leptin (the latter determined in a subgroup of 391 individuals). In conclusion, although total fat mass is the strongest predictor of circulating leptin, adipose tissue cellularity play an additional independent and important role.
早期研究表明，脂肪量是预测人类循环瘦素水平的唯一重要因素。在这项基于人群的横断面研究中，对447名女性和158名男性进行了研究，空腹血浆总瘦素与脂肪组织量和脂肪细胞大小相关，以研究脂肪组织细胞构成的重要性。获取腹部皮下脂肪活检样本，测定平均脂肪细胞体积、平均脂肪细胞重量和大小。还测量了空腹血清瘦素和体外瘦素分泌。通过生物电阻抗测量身体脂肪量。脂肪组织量和脂肪细胞大小与瘦素水平独立相关。脂肪量和脂肪细胞大小的偏相关系数分别为0.6（p<0.001）和0.3（p<0.01）。它们共同解释了2/3的瘦素方差（即调整后的r²）。脂肪量比脂肪细胞体积是更强的回归因子。这种关系独立于年龄、性别和脂肪细胞的瘦素分泌（后者在391名个体的亚组中测定）。总之，虽然总脂肪量是循环瘦素的最强预测因子，但脂肪组织细胞构成也发挥着额外的独立且重要的作用。
