Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden.
Int J Geriatr Psychiatry. 2012 Apr;27(4):409-14. doi: 10.1002/gps.2734. Epub 2011 May 10.
Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear.
We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness.
Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating cerebrovascular disease, showed no prediction of MMSE score.
The relation between plasma tHcy and cognition is not mediated by cerebrovascular disease as evaluated by pathological CT findings.
精神疾病老年患者的全血浆同型半胱氨酸（tHcy）浓度升高，且伴有血管疾病的患者的血浆 tHcy 浓度高于无血管疾病的患者。已有报道称，血浆 tHcy 与认知功能有关。但血浆 tHcy 影响认知功能的机制尚不清楚。
我们研究了 395 例连续入组的精神疾病老年患者的血浆 tHcy 与脑影像学（计算机断层扫描 [CT]）和认知（以简易精神状态检查 [MMSE] 评估）之间的关系。
年龄和血浆 tHcy 是 MMSE 评分的显著预测因素，而表明脑血管疾病的病理性 CT 发现对 MMSE 评分无预测作用。
病理性 CT 发现评估的脑血管疾病并不能介导血浆 tHcy 与认知之间的关系。
