Alajbegović Salem, Lepara Orhan, Hadžović-Džuvo Almira, Mutevelić-Turković Alma, Alajbegović Lejla, Zaćiragić Asija, Avdagić Nesina, Valjevac Amina, Babić Nermina, Dervišević Amela
Department of Endocrinology and Diabetes, Cantonal Hospital, Zenica, Bosnia and Herzegovina.
Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Glas (Zenica). 2017 Aug 1;14(2):257-261. doi: 10.17392/916-17.
Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.
目的 研究可能患有血管性痴呆（VD）的患者及年龄匹配的对照组的血清总同型半胱氨酸（tHcy）浓度，并确定可能患有VD的患者血清tHcy浓度与认知障碍之间的关联。方法 采用AxSYM系统上的荧光偏振免疫分析法测定血清tHcy浓度。通过简易精神状态检查表（MMSE）评分测试认知障碍。计算纳入研究的每个受试者的体重指数（BMI）。结果 两组之间的年龄、收缩压、舒张压和BMI无显著差异。对照组受试者的平均血清tHcy浓度为13.35µmol/L，而可能患有VD的患者显著更高，为19.45µmol/L（p=0.002）。发现可能患有VD的患者血清tHcy浓度与认知障碍之间存在负相关但不显著的关联。结论 可能患有VD的患者tHcy浓度升高表明Hcy在VD发病机制中可能具有独立作用。
