Sohn M, Füzesi L, Deutz F, Lagrange W, Kirkpatrick J C, Braun J C
Department of Urology, Medical Faculty of Technical University, Aachen, West Germany.
J Urol. 1990 Apr;143(4):805-7. doi: 10.1016/s0022-5347(17)40102-9.
The case of a signet ring cell carcinoma of the colon arising in an adenoma at the site of ureterosigmoidostomy after conversion to an ileal conduit is reported. Urine exposure to the colonic mucosa was present only for a short period before development of an adenoma with subsequent signet ring cell carcinoma transformation more than 15 years later. In the face of recent reports on adenocarcinoma in cases of bladder substitution or augmentation without any possible promoting influence of the fecal stream, the well known risk of neoplasia after sigmoidostomy remains unclear in its etiology.
本文报告了一例在输尿管乙状结肠吻合口处的腺瘤基础上发生的结肠印戒细胞癌病例，该患者在改做回肠导管术后发病。在腺瘤发生前，尿液与结肠黏膜的接触仅持续了很短一段时间，随后在15年多后发生了印戒细胞癌转变。鉴于近期有关膀胱替代或扩大手术病例中腺癌的报道，且无任何粪便流的促癌影响，乙状结肠造口术后众所周知的肿瘤形成风险在病因学上仍不明确。
