Hamazaki M, Kono S, Mimaya J, Ishihara A
Department of Pathology, Shizuoka Children's Hospital, Japan.
Acta Pathol Jpn. 1987 Oct;37(10):1679-84. doi: 10.1111/j.1440-1827.1987.tb02478.x.
Undifferentiated adenocarcinoma of the colon occurring in a 6-year-old boy was presented. The tumor characterized by the signet ring cell appearance developed in a polyp of the descending colon. The signet ring cell carcinoma is in general a rare morphologic form of colonic carcinoma. According to our review of the literature there have been described 16 patients under 10 years of age with colonic or rectal carcinoma, disclosing 2 cases of undifferentiated or signet ring cell carcinoma including the present case. In children, mucin producing adenocarcinoma is the most predominant type of colonic carcinoma, and 48% of the colonic carcinomas are of signet ring cell carcinoma in children under 17 years of age.