血糖异常时血清一氧化氮代谢产物增加。

Increased serum nitric oxide metabolites in dysglycaemia.

作者信息

Ghasemi Asghar, Zahediasl Saleh, Azimzadeh Iraj, Azizi Fereidoun

机构信息

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Ann Hum Biol. 2011 Sep;38(5):577-82. doi: 10.3109/03014460.2011.575384. Epub 2011 May 11.

DOI:10.3109/03014460.2011.575384

PMID:21561301

Abstract

BACKGROUND

Nitric oxide plays an important role in hyperglycaemia-induced endothelial dysfunction.

AIM

To investigate the relationship between serum nitric oxide metabolite (NO(x)) levels and fasting glucose in a population-based study.

SUBJECTS AND METHOD

Serum concentration of NO(x) was measured by the Griess method in 3,505 participants, aged 20-94 years, selected from a population-based study.

RESULTS

In men with impaired fasting glucose, each mmol/L increase in fasting serum glucose increased probability of serum NO(x) levels higher than median (> 25 μM) by 3.05-times (OR = 3.05 [95% CI, 1.15-8.07], p = 0.025) in non-adjusted and 3.76-times (OR = 3.76 [95% CI, 1.34-10.53, p = 0.012) in multivariable-adjusted analyses, while no significant associations were found in women. A direct association between fasting glucose categories and NO(x) values was found in men after multivariable adjustment (p = 0.006). Multivariable-adjusted serum NO(x) was significantly (p = 0.008) higher in diabetic men [34.1 (29.5-39.6) μmol/L] compared to non-diabetic ones [29.7 (26.5-33.2) μmol/L].

CONCLUSION

The findings show increased serum NO(x) levels in men, but not women, with impaired fasting glucose and diabetes in a population-based study.

摘要

背景

一氧化氮在高血糖诱导的内皮功能障碍中起重要作用。

目的

在一项基于人群的研究中调查血清一氧化氮代谢物（NO(x)）水平与空腹血糖之间的关系。

对象与方法

采用格里斯法测定了从一项基于人群的研究中选取的3505名年龄在20 - 94岁参与者的血清NO(x)浓度。

结果

在空腹血糖受损的男性中，空腹血清葡萄糖每增加1 mmol/L，血清NO(x)水平高于中位数（> 25 μM）的概率在未调整分析中增加3.05倍（OR = 3.05 [95% CI，1.15 - 8.07]，p = 0.025），在多变量调整分析中增加3.76倍（OR = 3.76 [95% CI，1.34 - 10.53，p = 0.012]），而在女性中未发现显著关联。多变量调整后，男性空腹血糖类别与NO(x)值之间存在直接关联（p = 0.006）。多变量调整后的血清NO(x)在糖尿病男性[34.1（29.5 - 39.6）μmol/L]中显著高于非糖尿病男性[29.7（26.5 - 33.2）μmol/L]（p = 0.008）。