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系统性红斑狼疮(SLE)背景下的组织细胞性坏死性淋巴结炎:SLE 中的组织细胞性坏死性淋巴结炎是否与皮肤损伤有关?

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

机构信息

Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, South Korea.

出版信息

Lupus. 2011 Jul;20(8):809-19. doi: 10.1177/0961203310397684. Epub 2011 May 11.

Abstract

Histiocytic necrotizing lymphadenitis (HNL), or Kikuchi's disease, is a benign and self-limiting lymphadenopathy that typically affects young Asian females. It presents with lymphadenopathy, usually cervical, accompanied by fever, chills and leukopenia. Although the association between systemic lupus erythematosus (SLE) and HNL is rare, the number of reports of HNL in SLE patients is increasing. We present nine cases of HNL in patients with SLE. Among the seven patients with diverse skin manifestations, three had skin manifestations that were histologically compatible with SLE. A review of previous reports in the literature showed that cutaneous involvement was commonly found in HNL in association with SLE. In the patients who had simultaneous onset of both diseases, lupus flare-ups were commonly observed. We suggest that HNL in SLE patients is associated with cutaneous manifestations. This report contributes to our understanding of the relationship between these diseases.

摘要

组织细胞坏死性淋巴结炎(HNL),又称菊池病,是一种良性、自限性的淋巴结病,主要影响年轻的亚裔女性。其特征为淋巴结病,通常为颈部淋巴结肿大,并伴有发热、寒战和白细胞减少。尽管系统性红斑狼疮(SLE)与 HNL 之间的关联较为罕见,但 SLE 患者中 HNL 的报告数量正在增加。我们报告了 9 例 SLE 患者合并 HNL。在 7 例具有不同皮肤表现的患者中,有 3 例的皮肤表现组织学上与 SLE 相符。对文献中的既往报告进行回顾显示,在 SLE 合并 HNL 患者中,皮肤受累较为常见。在同时发生两种疾病的患者中,常观察到狼疮发作。我们推测 SLE 患者的 HNL 与皮肤表现有关。本报告有助于我们了解这些疾病之间的关系。

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