Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Hospital, Gunma, Japan.
Pancreas. 2011 Jul;40(5):747-52. doi: 10.1097/MPA.0b013e318215ac22.
The objective of this study was to demonstrate the feasibility of pancreatic perfusion computed tomography (CT) and review pancreatic perfusion measurements by various imaging modalities.
Dynamic CT data from 8 patients (4 men; mean age, 64.8 [SD, 12.1] years; range, 40-80 years) with normal pancreas were analyzed using 2 analytical models: the maximum-slope and compartment-model methods. Literature search was also performed.
Although the perfusion value estimated by the maximum-slope method (88.1 [SD, 42.1] mL/min per 100 mL) was significantly smaller than that of the compartment-model method (127.0 [SD, 70.5]; P < 0.001), there was a linear correlation between them (r = 0.97, P < 0.001). In the literature review, 15 studies that reported the absolute values of normal pancreatic perfusion, by using perfusion CT, dynamic magnetic resonance imaging, hydrogen gas clearance method, and 15O-H2O-positron emission tomography were found. The reported mean values of normal pancreatic perfusion ranged from 38.4 to 356 mL/min per 100 mL, and there was a great deal of individual variation.
Perfusion CT may provide reliable perfusion measurements of the pancreas, and the normal value was estimated at around 100 mL/min per 100 mL with a great deal of individual variation. The maximum-slope method may provide a lower perfusion value compared with the compartment-model method.
本研究旨在展示胰腺灌注 CT（CT）的可行性，并综述各种成像方式的胰腺灌注测量。
分析 8 例（4 名男性；平均年龄 64.8[标准差 12.1]岁；年龄范围 40-80 岁）正常胰腺的动态 CT 数据，使用 2 种分析模型：最大斜率和房室模型法。还进行了文献检索。
尽管最大斜率法（88.1[标准差 42.1]mL/min/100mL）估计的灌注值明显小于房室模型法（127.0[标准差 70.5]；P<0.001），但两者之间存在线性相关（r=0.97，P<0.001）。在文献综述中，发现了 15 项使用灌注 CT、动态磁共振成像、氢气清除法报告正常胰腺灌注绝对值的研究。报告的正常胰腺灌注平均值范围为 38.4 至 356mL/min/100mL，个体差异较大。
灌注 CT 可能提供可靠的胰腺灌注测量值，正常值估计约为 100mL/min/100mL，个体差异较大。与房室模型法相比，最大斜率法可能提供较低的灌注值。
