Cai Shuang, Bagby Taryn R, Forrest M Laird
Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Ave, Lawrence, KS 66047, USA.
Ther Deliv. 2011 Nov;2(11):1467-84. doi: 10.4155/tde.11.112.
Conventional oral and intravenous chemotherapies permeate throughout the body, exposing healthy tissues to similar cytotoxic drug levels as tumors. This leads to significant dose-limiting toxicities that may prevent patients from receiving sufficient treatment to overcome cancers. Therefore, a number of locoregional drug-delivery strategies have been evaluated and implemented in preclinical studies, clinical trials and in practice, in the past decades to minimize systemic toxicities from chemotherapeutic agents and to improve treatment outcomes. Localized treatment is beneficial because many cancers, such as melanoma, peritoneal cancer and breast cancer, advance locally adjacent to the site of the primary tumors prior to their circulatory invasion. In this article, we will review the feasibility, safety and efficacy of multiple localized chemotherapies in clinical use and preclinical development.
传统的口服和静脉化疗药物会遍布全身，使健康组织接触到与肿瘤相似的细胞毒性药物水平。这会导致严重的剂量限制毒性，可能使患者无法接受足够的治疗来战胜癌症。因此，在过去几十年里，在临床前研究、临床试验及实际应用中，人们评估并实施了多种局部给药策略，以尽量减少化疗药物的全身毒性并改善治疗效果。局部治疗是有益的，因为许多癌症，如黑色素瘤、腹膜癌和乳腺癌，在发生血行转移之前，会在原发肿瘤部位附近局部进展。在本文中，我们将综述多种局部化疗在临床应用和临床前开发中的可行性、安全性和有效性。
