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片上磁驱动机器人结合超声振动用于单细胞操作。

On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations.

机构信息

Department of Mechanical Science and Engineering, Nagoya University, Nagoya, Japan.

出版信息

Lab Chip. 2011 Jun 21;11(12):2049-54. doi: 10.1039/c1lc20164f. Epub 2011 May 12.

DOI:10.1039/c1lc20164f
PMID:21562668
Abstract

This paper presents an innovative driving method for an on-chip robot actuated by permanent magnets in a microfluidic chip. A piezoelectric ceramic is applied to induce ultrasonic vibration to the microfluidic chip and the high-frequency vibration reduces the effective friction on the MMT significantly. As a result, we achieved 1.1 micrometre positioning accuracy of the microrobot, which is 100 times higher accuracy than without vibration. The response speed is also improved and the microrobot can be actuated with a speed of 5.5 mm s(-1) in 3 degrees of freedom. The novelty of the ultrasonic vibration appears in the output force as well. Contrary to the reduction of friction on the microrobot, the output force increased twice as much by the ultrasonic vibration. Using this high accuracy, high speed, and high power microrobot, swine oocyte manipulations are presented in a microfluidic chip.

摘要

本文提出了一种用于微流控芯片中永磁体驱动的片上机器人的创新驱动方法。采用压电陶瓷对微流控芯片施加超声振动,高频振动可显著降低 MMT 的有效摩擦力。结果,我们实现了微机器人 1.1 微米的定位精度,比无振动时提高了 100 倍。响应速度也得到了提高,微机器人可以以 5.5 毫米/秒的速度在三维自由度上进行驱动。超声振动的新颖之处在于输出力。与微机器人上摩擦力的减小相反,超声振动使输出力增加了两倍。利用这种高精度、高速、高功率的微机器人,在微流控芯片中进行了猪卵母细胞的操作。

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