未经功能化修饰与功能化修饰石墨烯的纳/生物差异性相互作用及毒性效应。
Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene.
机构信息
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, 682 041, Kerala, India.
出版信息
Nanoscale. 2011 Jun;3(6):2461-4. doi: 10.1039/c1nr10172b. Epub 2011 May 12.
PMID:21562671
Abstract
We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.
摘要
我们报告了羧基官能化石墨烯对缓和其与细胞强烈的疏水相互作用及相关毒性作用的影响。研究发现，原始石墨烯在细胞膜上积累，导致高氧化应激，从而引发细胞凋亡，而羧基官能化的亲水性石墨烯则被细胞内化，而没有引起任何毒性。
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