一锅法多组分合成多取代吡咯。
A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Chem Commun (Camb). 2011 Jun 21;47(23):6620-2. doi: 10.1039/c1cc11363a. Epub 2011 May 12.
PMID:21562679
Abstract
Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.
摘要
多取代吡咯可以通过一种从伯胺、乙二醛和 2-溴苯乙酮开始的一锅多组分反应，在吡啶和回流乙腈中的存在下，以中等产率高效合成。该方法被用于合成高度取代的苯并[g]吲哚。
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