Steinmetz Adam B, Skosnik Patrick D, Edwards Chad R, Bolbecker Amanda R, Steinmetz Joseph E, Hetrick William P
Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA.
Learn Behav. 2011 Dec;39(4):358-70. doi: 10.3758/s13420-011-0031-9.
Delay eye-blink conditioning is an associative learning task that can be utilized to probe the functional integrity of the cerebellum and related neural circuits. Typically, a single interstimulus interval (ISI) is utilized, and the amplitude of the conditioned response (CR) is the primary dependent variable. To study the timing of the CR, an ISI shift can be introduced (e.g., shifting the ISI from 350 to 850 ms). In each phase, a conditioned stimulus (e.g., a 400- or 900-ms tone) coterminates with a 50-ms corneal air puff unconditioned stimulus. The ability of a subject to adjust the CR to the changing ISI constitutes a critical timing shift. The feasibility of this procedure was examined in healthy human participants (N = 58) using a bidirectional ISI shift procedure while cortical event-related brain potentials were measured. CR acquisition was faster and the responses better timed when a short ISI was used. After the ISI shift, additional training was necessary to allow asymptotic responding at the new ISI. Interestingly, auditory event-related potentials to the CR were not associated with conditioning measures at either ISI.
延迟眨眼条件反射是一种关联学习任务，可用于探究小脑及相关神经回路的功能完整性。通常，使用单个刺激间隔（ISI），条件反应（CR）的幅度是主要的因变量。为了研究CR的时间，可引入ISI偏移（例如，将ISI从350毫秒偏移到850毫秒）。在每个阶段，条件刺激（例如，400或900毫秒的音调）与50毫秒的角膜吹气非条件刺激同时终止。受试者将CR调整到变化的ISI的能力构成关键的时间偏移。在健康人类参与者（N = 58）中使用双向ISI偏移程序检查了该程序的可行性，同时测量了皮层事件相关脑电位。当使用短ISI时，CR习得更快且反应时间更合适。在ISI偏移后，需要额外的训练以在新的ISI下达到渐近反应。有趣的是，对CR的听觉事件相关电位与任一ISI下的条件反射测量均无关。
