Department of Radiology, University of California San Francisco, San Francisco, California, USA.
J Magn Reson Imaging. 2011 Mar;33(3):655-60. doi: 10.1002/jmri.22501.
To evaluate the blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) findings in kidneys of patients with diabetic nephropathy.
BOLD MRI of the kidneys (1.5 T, multigradient-recalled-echo sequence with 12 echoes) was performed in 20 patients with diabetic nephropathy (moderate to severe chronic kidney disease: n = 14; mild chronic kidney disease: n = 6), and seven healthy volunteers. The medullary and cortical R2* values were compared between patients with diabetic nephropathy and healthy volunteers using Student's t-tests.
The mean medullary R2* values were lower in patients with diabetic nephropathy compared to healthy volunteers (13.8 ± 2.4 sec(-1) vs. 19.3 ± 1.2 sec(-1), P = 0.0002). The cortical R2* values were not significantly different between the two groups (11.1 ± 0.9 sec(-1) vs. 11.5 ± 0.7 sec(-1), P = 0.7). A multiple logistic regression model using patient age, gender, and degree of chronic kidney disease (none, mild, or moderate to severe) as variables showed that the degree of kidney disease was independently associated with a decrease in medullary R2* values (P = 0.005).
The medullary R2* values were lower in patients with diabetic nephropathy compared to healthy volunteers.
评估糖尿病肾病患者肾脏的血氧水平依赖（BOLD）磁共振成像（MRI）表现。
对 20 例糖尿病肾病患者（中重度慢性肾脏病：n=14；轻度慢性肾脏病：n=6）和 7 名健康志愿者进行肾脏 BOLD MRI（1.5 T，多梯度回波序列，12 个回波）检查。采用 Student's t 检验比较糖尿病肾病患者与健康志愿者的肾髓质和皮质 R2*值。
与健康志愿者相比，糖尿病肾病患者的平均肾髓质 R2值较低（13.8±2.4 sec(-1) vs. 19.3±1.2 sec(-1)，P=0.0002）。两组间皮质 R2值无显著差异（11.1±0.9 sec(-1) vs. 11.5±0.7 sec(-1)，P=0.7）。采用患者年龄、性别和慢性肾脏病程度（无、轻度或中重度）作为变量的多元逻辑回归模型显示，肾脏病程度与肾髓质 R2*值降低独立相关（P=0.005）。
与健康志愿者相比，糖尿病肾病患者的肾髓质 R2*值较低。
