Anand Aashish, Sheha Hosam, Teng Christopher C, Liebmann Jeffrey M, Ritch Robert, Tello Celso
Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York, USA.
Ophthalmic Surg Lasers Imaging. 2011 May-Jun;42(3):184-9. doi: 10.3928/15428877-20110426-01.
To determine the safety and efficacy of amniotic membrane graft in glaucoma drainage device surgery.
Institutional retrospective case series of 44 patients undergoing glaucoma drainage device implantation with use of 300-μm thick amniotic membrane as a patch graft. Endpoints assessed were tube exposure, graft thinning, graft clarity, graft-related infection, and inflammation.
A total of 41 (93%) eyes had an uneventful course over a mean follow-up of 22 ± 3 months (range: 17 to 28 months). Tube exposure and hypotony each occurred in one eye and were successfully treated with a tube revision using double pericardial and amniotic membrane patch graft. The translucency of amniotic membrane graft enabled good visualization of the occluding suture when performing laser suture lysis in 16 eyes. Sequential anterior segment optical coherence tomography showed stable amniotic membrane graft thickness with a change from low to moderate reflectivity in the subconjunctival-graft bilayer.
Amniotic membrane graft offers good tectonic support and allows direct visualization of the underlying tube.
确定羊膜移植片在青光眼引流装置手术中的安全性和有效性。
对44例行青光眼引流装置植入术并使用300μm厚羊膜作为补片移植的患者进行机构回顾性病例系列研究。评估的终点指标包括引流管暴露、移植片变薄、移植片透明度、移植片相关感染及炎症。
在平均22±3个月（范围：17至28个月）的随访期内，共有41只眼（93%）病情平稳。引流管暴露和低眼压各发生于1只眼，通过使用双层心包和羊膜补片移植进行引流管修复成功治疗。在16只眼中，当进行激光缝线溶解时，羊膜移植片的半透明性使封堵缝线能够清晰可见。连续眼前节光学相干断层扫描显示羊膜移植片厚度稳定，结膜下移植片双层的反射率从低变为中等。
羊膜移植片提供了良好的结构支撑，并能直接观察到下方的引流管。
