Zhou Di, Zhou Xiao Yi, Mas-Ramirez Alma Michelle, Kim Chaesik, Juzych Mark S, Nassiri Nariman, Hughes Bret A
Department of Ophthalmology, School of Medicine, Kresge Eye Institute, Wayne State University, Detroit, MI, USA.
J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):411-418. doi: 10.4103/jovr.jovr_219_17.
To investigate the frequency of conjunctival erosions in a series of patients who underwent Ahmed valve implantation in a tertiary referral center and to study risk factors associated with the conjunctival erosions.
This is a single-center, retrospective case-control study of all patients who underwent Ahmed valve implantation between October 2006 and July 2016 at the Kresge Eye Institute in Detroit, Michigan. The series consisted of 306 eyes (277 patients) that underwent Ahmed valve implantation. The rate of conjunctival erosions was determined. Univariate, bivariate, and Cox-proportional hazard analyses were performed to identify factors associated with conjunctival erosions.
During the study period, 23 erosions occurred in 306 eyes (7.52%). Aphakia was significantly more common in eyes with erosions ( < 0.05). Aphakia ( = 0.02), uveitic glaucoma ( = 0.03), and longer post-operative use of topical steroids ( < 0.04) significantly increased the risk of erosions based on the Cox model. There were similar rates of erosions with each type of patch graft. No conjunctival erosion was observed after using the modified scleral tunnel method ( = 10).
The overall erosion rate was 7.52% in our series. Uveitic glaucoma, aphakia, and longer post-operative use of topical steroids were significantly associated with conjunctival erosions.
在一家三级转诊中心，调查一系列接受艾哈迈德瓣膜植入术的患者结膜糜烂的发生率，并研究与结膜糜烂相关的危险因素。
这是一项单中心回顾性病例对照研究，研究对象为2006年10月至2016年7月期间在密歇根州底特律市克雷斯吉眼科研究所接受艾哈迈德瓣膜植入术的所有患者。该系列包括306只眼（277例患者）接受了艾哈迈德瓣膜植入术。确定结膜糜烂的发生率。进行单因素、双因素和Cox比例风险分析，以确定与结膜糜烂相关的因素。
在研究期间，306只眼中有23只发生糜烂（7.52%）。无晶状体眼在发生糜烂的眼中明显更常见（<0.05）。根据Cox模型，无晶状体眼（=0.02）、葡萄膜炎性青光眼（=0.03）和术后长期使用局部类固醇（<0.04）显著增加了糜烂的风险。每种类型的补片移植的糜烂发生率相似。使用改良巩膜隧道法（=10）后未观察到结膜糜烂。
在我们的系列研究中，总体糜烂率为7.52%。葡萄膜炎性青光眼、无晶状体眼和术后长期使用局部类固醇与结膜糜烂显著相关。
