Wyatt S, Shooter E M, Davies A M
Department of Anatomy, St. George's Hospital Medical School, Tooting, London, England.
Neuron. 1990 Mar;4(3):421-7. doi: 10.1016/0896-6273(90)90054-j.
We have studied the expression of NGF receptor (NGFR) mRNA in the mouse trigeminal system at closely staged intervals throughout development. The level of NGFR mRNA per neuron is at a constant low level before the earliest axons reach the target field and increases 5-fold to plateau shortly after the arrival of the last axons. NGFR mRNA expression in developing target skin is restricted to mesenchyme, precedes the arrival of the earliest axons, and increases throughout the phase of target field innervation. These findings suggest that NGFR expression on sensory neurons occurs at a low level prior to target field innervation and is up-regulated with this event, and they raise the possibility that NGFRs on mesenchymal cells restrict the distribution of NGF in the target field.
我们在小鼠三叉神经系统发育的各个紧密阶段，研究了NGF受体（NGFR）mRNA的表达情况。在最早的轴突到达靶区域之前，每个神经元的NGFR mRNA水平处于恒定的低水平，而在最后一批轴突到达后不久，该水平会增加5倍并趋于平稳。发育中的靶皮肤中NGFR mRNA的表达仅限于间充质，在最早的轴突到达之前就已出现，并在靶区域神经支配阶段持续增加。这些发现表明，感觉神经元上的NGFR表达在靶区域神经支配之前处于低水平，并随着这一事件而上调，这也增加了间充质细胞上的NGFR限制靶区域中NGF分布的可能性。
