Yang Zhenhong, Wang Rongliang, Zheng Yangmin, Luo Yumin
1Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
2Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China.
Aging Dis. 2023 Apr 1;14(2):287-289. doi: 10.14336/AD.2022.0823.
Erythropoietin is generally assumed to have protective effects against multiple diseases, especially ischemic stroke, and myocardial infarctions. The theory behind Erythropoietin's (EPO) protective effects has been misconstrued in the scientific community to a degree, with assumptions made that the β common receptor (βcR) in the heteroreceptor EPO receptor (EPOR)/βcR is responsible for these protective effects. Our purpose with this opinion article is to convey our concern for the general assumption of the importance of βcR in EPO's protective effect and to emphasize the necessity of further research in this field.
一般认为促红细胞生成素对多种疾病具有保护作用，尤其是缺血性中风和心肌梗死。促红细胞生成素（EPO）保护作用背后的理论在科学界一定程度上被误解了，有人认为异源受体促红细胞生成素受体（EPOR）/β共同受体（βcR）中的β共同受体（βcR）负责这些保护作用。我们撰写这篇观点文章的目的是表达我们对普遍认为βcR在EPO保护作用中重要性的担忧，并强调在该领域进一步研究的必要性。
