Adhesion and Angiogenesis Group, Centre for Tumour Biology, Barts Cancer Institute - A CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom.
Curr Opin Cell Biol. 2011 Oct;23(5):630-7. doi: 10.1016/j.ceb.2011.03.014. Epub 2011 May 10.
Integrins are a family of cell-extracellular matrix adhesion molecules that play important roles in tumor angiogenesis. αvβ3-Integrin has received much attention as a potential anti-angiogenic target because it is upregulated in tumor-associated blood vessels. Agents targeting αvβ3-integrin are now showing some success in phase III clinical trails for the treatment of glioblastoma, but the exact function of this integrin in tumor angiogenesis is still relatively unknown. This review highlights some of the recent data illustrating that β3-integrins play both pro-angiogenic and anti-angiogenic roles in tumor angiogenesis depending on the context. Specifically we will discuss how the following differentially influence β3-integrin's role in tumor angiogenesis: first, cell-matrix interactions, second, β3-integrin inhibitor doses, third, cell type, and fourth, other interacting molecules.
整合素是细胞-细胞外基质黏附分子家族，在肿瘤血管生成中发挥重要作用。αvβ3-整合素作为一种潜在的抗血管生成靶点受到了广泛关注，因为它在肿瘤相关血管中上调。目前，靶向αvβ3-整合素的药物在治疗胶质母细胞瘤的 III 期临床试验中取得了一些成功，但该整合素在肿瘤血管生成中的确切功能仍知之甚少。本综述强调了一些最近的数据，这些数据表明β3-整合素在肿瘤血管生成中具有促血管生成和抗血管生成作用，具体取决于具体情况。具体来说，我们将讨论以下因素如何不同程度地影响β3-整合素在肿瘤血管生成中的作用：第一，细胞-基质相互作用；第二，β3-整合素抑制剂剂量；第三，细胞类型；第四，其他相互作用的分子。
