Li Qingling, Lan Ting, Xie Jian, Lu Youguang, Zheng Dali, Su Bohua
Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Front Oncol. 2022 Feb 11;12:812480. doi: 10.3389/fonc.2022.812480. eCollection 2022.
Integrins, a family of adhesion molecules generally exist on the cell surface, are essential for regulating cell growth and its function. As a bi-directional signaling molecule, they mediate cell-cell and cell-extracellular matrix interaction. The recognitions of their key roles in many human pathologies, including autoimmunity, thrombosis and neoplasia, have revealed their great potential as a therapeutic target. This paper focuses on the activation of integrins, the role of integrins in tumorigenesis and progression, and advances of integrin-dependent tumor therapeutics in recent years. It is expected that understanding function and signaling transmission will fully exploit potentialities of integrin as a novel target for tumors.
整合素是一类通常存在于细胞表面的黏附分子，对调节细胞生长及其功能至关重要。作为一种双向信号分子，它们介导细胞间和细胞与细胞外基质的相互作用。对其在包括自身免疫、血栓形成和肿瘤形成在内的许多人类疾病中的关键作用的认识，揭示了它们作为治疗靶点的巨大潜力。本文重点关注整合素的激活、整合素在肿瘤发生和进展中的作用以及近年来整合素依赖性肿瘤治疗的进展。预计对其功能和信号转导的理解将充分挖掘整合素作为肿瘤新靶点的潜力。
