Baez Maria Andrea, Avery Jonathan
Department of Psychiatry, Montefiore Medical Center, Bronx, New York 10128, USA.
Am J Geriatr Pharmacother. 2011 Jun;9(3):190-3. doi: 10.1016/j.amjopharm.2011.04.005. Epub 2011 May 12.
Drug-induced parkinsonism is a common medication side effect.
The present report describes the case of a depressed elderly woman who developed parkinsonism after receiving risperidone and who had improvement of her depression and parkinsonism after electroconvulsive therapy (ECT).
A 67-year-old white female was admitted to a psychiatry ward for a major depressive episode with psychotic features. The patient developed pronounced parkinsonian features after taking risperidone, which did not improve with discontinuation of the drug, or with benztropine and carbidopa/levodopa. A total score of 6 was achieved using Naranjo's adverse drug reaction causality algorithm, suggesting risperidone was a probable cause of this adverse event. The patient's depression and parkinsonian symptoms did not improve until after initiation of ECT. After 19 treatments, the patient had resolution of her depression and only mild bradykinesia remained.
This was a case of probable drug-induced parkinsonism in an elderly woman who had improvement of her depression and parkinsonism after receiving ECT.
药物性帕金森综合征是一种常见的药物副作用。
本报告描述了一名老年抑郁症女性患者的病例，该患者在服用利培酮后出现帕金森综合征，并在接受电休克治疗（ECT）后抑郁症状和帕金森综合征均有所改善。
一名67岁的白人女性因伴有精神病性特征的重度抑郁发作入住精神科病房。该患者在服用利培酮后出现明显的帕金森病特征，停药、使用苯海索及卡比多巴/左旋多巴治疗后均未改善。使用Naranjo药物不良反应因果关系算法得出的总分是6分，提示利培酮可能是该不良事件的原因。患者的抑郁症状和帕金森病症状在开始ECT治疗后才有所改善。经过19次治疗后，患者的抑郁症状消失，仅残留轻度运动迟缓。
这是一例老年女性可能由药物引起的帕金森综合征病例，该患者在接受ECT治疗后抑郁症状和帕金森综合征均有所改善。
