School of Life Science, Anhui University, Hefei 230039, Anhui, China.
J Sci Food Agric. 2011 Sep;91(12):2180-5. doi: 10.1002/jsfa.4436. Epub 2011 May 5.
Polysaccharides extracted from fungi or algae have shown a variety of medical activities, and the exploitation of polysaccharides for application in pharmacy has been very promising. In this study, the immunomodulatory properties of polysaccharides from Morchella esculenta were investigated to identify immunostimulatory activity and potentially contribute to the therapeutic potential of Morchella esculenta.
A water-soluble polysaccharide, MEP, was obtained from the fermentation broth of Morchella esculenta. Two fractions of this polysaccharide (MEP-I and MEP-II) were extracted and purified. High-performance gel permeation chromatography analysis showed the average molecular weights of two polysaccharides. Structural properties and compositions of these two fractions were examined by Fourier transform infrared and a high-performance liquid chromatography with an evaporative light scattering detector. Active experiments suggested that the MEP had typical immunostimulatory activity.
These bioactivity tests showed that the polysaccharides from Morchella esculenta presented significant immune modulating activity, and this finding may offer the basis for the popular use of polysaccharides in functional foods or medicine.
真菌或藻类中提取的多糖具有多种医疗活性，多糖在药学中的应用具有广阔的前景。本研究旨在探讨羊肚菌多糖的免疫调节特性，以确定其免疫刺激活性，并可能为羊肚菌的治疗潜力做出贡献。
从羊肚菌发酵液中得到一种水溶性多糖 MEP。从该多糖中提取并纯化出两个级分（MEP-I 和 MEP-II）。高效凝胶渗透色谱分析表明两种多糖的平均分子量。通过傅里叶变换红外光谱和高效液相色谱-蒸发光散射检测器对这两个级分的结构特性和组成进行了检测。活性实验表明，MEP 具有典型的免疫刺激活性。
这些生物活性测试表明，羊肚菌多糖具有显著的免疫调节活性，这一发现可能为多糖在功能性食品或药物中的广泛应用提供基础。
