Department of Immunopathology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Clin Lab Anal. 2011;25(3):156-61. doi: 10.1002/jcla.20449.
The association of celiac disease with type 1 diabetes mellitus is known, but the evolution of celiac disease is most frequently asymptomatic, without any clinical signs. Thus, diagnosis is impossible to make in the absence of serological tests. Our study aimed to determine the prevalence and the efficiency of IgA antitissue transglutaminase antibodies in the screening of celiac disease in children with type 1 diabetes mellitus.
During the course of 2008-2009, we performed an analytical clinical study that included the determination of IgA antitissue transglutaminase antibodies in a group of 119 children with type 1 diabetes mellitus. Fifty-seven percent of the subjects were male and 43% were female, with a mean age of 11±4 years.
By evaluating IgA antitissue transglutaminase antibodies, we obtained a prevalence of 9.2% in children with type 1 diabetes mellitus, with a sensitivity and specificity of 80 and 82.6%, respectively.
There is an increased prevalence of IgA antitissue transglutaminase antibodies, which suggests the need to use this method as an effective first-line test in the screening of celiac disease in children with type 1 diabetes mellitus.
本研究旨在确定 IgA 抗组织转谷氨酰胺酶抗体在 1 型糖尿病患儿中筛查乳糜泻的患病率和效率。
在 2008-2009 年期间，我们进行了一项分析性临床研究，包括测定 119 例 1 型糖尿病患儿的 IgA 抗组织转谷氨酰胺酶抗体。研究对象中 57%为男性，43%为女性，平均年龄为 11±4 岁。
通过评估 IgA 抗组织转谷氨酰胺酶抗体，我们在 1 型糖尿病患儿中获得了 9.2%的患病率，其敏感性和特异性分别为 80%和 82.6%。
存在 IgA 抗组织转谷氨酰胺酶抗体的患病率增加，这提示需要将该方法作为 1 型糖尿病患儿乳糜泻筛查的有效一线检测方法。
