Lawrence L, Kline K, Miller-Graber P, Siegel A, Kurcz E, Fisher M, Bump K
Dept. of Anim Sci., University of Illinois, Urbana 61801.
J Anim Sci. 1990 Mar;68(3):673-7. doi: 10.2527/1990.683673x.
Twenty-two Standardbred horses in race training were used in a crossover experiment to determine the effect of oral sodium bicarbonate (NaHCO3) administration on performance and metabolic responses to a 1.6-km (1-mile) race. Horses were paired and one horse in each pair was treated with either NaHCO3 (300 mg/kg BW) or a placebo, 2.5 h before they raced against each other. Each horse was scheduled to compete in two races, approximately 1 wk apart, one on each treatment. Horses always raced in the same pairs. Fourteen horses successfully completed both races. Jugular blood samples were obtained 1.5 h after treatment (rest), immediately before racing, 5 min post-race and 15 min post-race. In six horses, blood samples also were obtained 30 min post-race. Race times averaged 1.1 s faster after NaHCO3 treatment (P less than .1). Sodium bicarbonate treatment also elevated blood pH (P less than .05). In the horses sampled 15 and 30 min post-race, blood lactate disappearance was faster with the NaHCO3 treatment (P less than .05). The NaHCO3 may delay the fatigue precipitated by i.m. acidosis. Because other factors may limit performance (musculoskeletal soundness, cardiovascular and respiratory ability), NaHCO3 would not be expected to enhance the performance of all horses. However, the effect of NaHCO3 on lactate clearance may have implications for all intensively worked horses; because lactate and the associated hydrogen ions are believed to cause muscle damage and soreness, any mechanism to increase their removal rate could benefit the equine athlete.
在一项交叉试验中,选用了22匹处于比赛训练阶段的标准赛马,以确定口服碳酸氢钠(NaHCO₃)对1.6公里(1英里)比赛的表现及代谢反应的影响。马匹被配对,每对中的一匹马在与另一匹马比赛前2.5小时接受NaHCO₃(300毫克/千克体重)或安慰剂治疗。每匹马计划参加两场比赛,两场比赛间隔约1周,每种治疗各参加一场。马匹始终与同一配对的马比赛。14匹马成功完成了两场比赛。在治疗后1.5小时(休息时)、比赛前即刻、赛后5分钟和赛后15分钟采集颈静脉血样。在6匹马中,还在赛后30分钟采集了血样。NaHCO₃治疗后比赛时间平均快了1.1秒(P小于0.1)。碳酸氢钠治疗还提高了血液pH值(P小于0.05)。在赛后15分钟和30分钟采样的马匹中,NaHCO₃治疗使血乳酸清除更快(P小于0.05)。NaHCO₃可能会延迟因肌肉注射酸中毒引发的疲劳。由于其他因素可能会限制表现(肌肉骨骼健康状况、心血管和呼吸能力),预计NaHCO₃不会提高所有马匹的表现。然而,NaHCO₃对乳酸清除的影响可能对所有高强度工作的马匹都有意义;因为乳酸和相关的氢离子被认为会导致肌肉损伤和酸痛,任何提高其清除率的机制都可能使赛马受益。