Institut Curie, Centre de Recherche, UMR 168, 26 rue d'Ulm, F-75005, Paris, France.
Phys Rev Lett. 2011 Apr 15;106(15):158101. doi: 10.1103/PhysRevLett.106.158101. Epub 2011 Apr 11.
Treating the epithelium as an incompressible fluid adjacent to a viscoelastic stroma, we find a novel hydrodynamic instability that leads to the formation of protrusions of the epithelium into the stroma. This instability is a candidate for epithelial fingering observed in vivo. It occurs for sufficiently large viscosity, cell-division rate and thickness of the dividing region in the epithelium. Our work provides physical insight into a potential mechanism by which interfaces between epithelia and stromas undulate and potentially by which tissue dysplasia leads to cancerous invasion.
将上皮组织视为毗邻黏弹性基质的不可压缩流体，我们发现了一种新的流体动力学不稳定性，这种不稳定性会导致上皮组织向基质中突起。这种不稳定性可能是体内观察到的上皮指状突的候选机制。当上皮组织中的黏度、细胞分裂率和分裂区域的厚度足够大时，就会发生这种不稳定性。我们的工作为上皮组织和基质之间的界面波动以及组织发育不良如何导致癌症侵袭的潜在机制提供了物理见解。
