Department of Haematological Medicine, King's College London, London, UK.
Br J Haematol. 2011 Jul;154(2):216-22. doi: 10.1111/j.1365-2141.2011.08725.x. Epub 2011 May 14.
Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.
进行性慢性淋巴细胞白血病的特征是肿瘤 B 细胞在组织中的积累，并与预后生物标志物的表达相关，如 CD38、CD49d 和基质金属蛋白酶-9（MMP9），这些标志物参与迁移和组织侵袭。在这项研究中，我们研究了这些分子之间的物理关系，并证明 CD38、CD49d、MMP9 和 CD44 在一个超分子细胞表面复合物中物理相关。我们的发现为这些蛋白的表达与预后之间的相关性提供了分子基础，并且由于该复合物不存在于正常 B 细胞中，因此提示了一个新的白血病特异性治疗靶点。
