Zhu Min, Yu Jun, Zhou Wenli, Fu Xiangning
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhongguo Fei Ai Za Zhi. 2011 May;14(5):441-5. doi: 10.3779/j.issn.1009-3419.2011.05.11.
Lung cancer is a complicated disease involving many genes and important biologic processes. Genetic variation or aberrant expression of some oncogenes, tumor suppressor genes and DNA repair genes might be related to its incidence and development. How to find out the pathogenic factors of lung cancer and its molecular mechanism of multistage carcinogenesis from massive data is a key question that researchers and clinicians must answer. The bio-chip technology provides a high throughput and efficient method for cancer research. The latest bio-chip progress in lung cancer research is summarized in this minireview.
肺癌是一种涉及众多基因和重要生物学过程的复杂疾病。某些癌基因、肿瘤抑制基因和DNA修复基因的遗传变异或异常表达可能与其发生和发展有关。如何从海量数据中找出肺癌的致病因素及其多阶段致癌的分子机制，是研究人员和临床医生必须回答的关键问题。生物芯片技术为癌症研究提供了一种高通量且高效的方法。本综述总结了肺癌研究中生物芯片的最新进展。
