Photomedicine Section, Charles C. Harris Skin and Cancer Pavilion, Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NY, USA.
Dermatitis. 2011 May;22(3):147-54.
Chronic actinic dermatitis (CAD) is a rare photosensitivity disorder with scant epidemiologic data.
To evaluate demographic data and results of photopatch and patch tests over a 25-year period.
Retrospective chart review of patients with CAD from 1993 to 2009.
Forty patients had a mean age of 57.8 years, and 27 (67.5%) were men. Twelve patients (30%) were skin types I and II, and 17 (42.5%) were skin types V and VI. Nine patients (22.5%) were younger than 50 years, and 4 of these (44.4%) were men. One of the nine patients (11.1%) was skin type I, and 4 (44.4%) were skin types V and VI. Carba mix and para-phenylenediamine were the two most commonly positive agents in patch tests. Sunscreens and plants and plant derivatives were the most commonly positive agents in photopatch tests.
Our findings suggest a trend of two new classes of North American patients at our institution being diagnosed with CAD-younger women with skin types IV to VI and older men with skin types I to III. We observed a greater-than-expected number of positive patch-test reactions to para-phenylenediamine. We suggest that patch testing and photopatch testing of individuals may be useful adjuncts in the assessment of CAD.
慢性光化性皮炎（CAD）是一种罕见的光敏性疾病，其流行病学数据很少。
评估 25 年来光斑贴和斑贴试验的人口统计学数据和结果。
对 1993 年至 2009 年 CAD 患者的病历进行回顾性分析。
40 例患者的平均年龄为 57.8 岁，27 例（67.5%）为男性。12 例（30%）患者的皮肤类型为 I 型和 II 型，17 例（42.5%）患者的皮肤类型为 V 型和 VI 型。9 例（22.5%）患者年龄小于 50 岁，其中 4 例（44.4%）为男性。这 9 例患者中有 1 例（11.1%）患者的皮肤类型为 I 型，4 例（44.4%）患者的皮肤类型为 V 型和 VI 型。在斑贴试验中，卡巴混合物和对苯二胺是最常见的两种阳性试剂。在光斑贴试验中，防晒霜、植物及其衍生物是最常见的阳性试剂。
我们的发现表明，在我们的机构中，有两类新的北美 CAD 患者群体的诊断趋势，即皮肤类型为 IV 至 VI 型的年轻女性和皮肤类型为 I 至 III 型的老年男性。我们观察到对苯二胺的阳性斑贴试验反应数量高于预期。我们建议，对个人进行斑贴试验和光斑贴试验可能是评估 CAD 的有用辅助手段。
