Department of Dermatology, Faculty of Medicine, Adverse Drug Reaction Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dermatitis. 2011 May;22(3):155-60.
To date, even though there are some large studies on adverse reactions related to fluoroquinolones, there is no comprehensive study focusing on cutaneous adverse drug reactions associated with their use.
To demonstrate the pattern of cutaneous reaction related to the administration of each type of fluoroquinolone and to study the cross-sensitivity between various types of fluoroquinolones.
Voluntary reports of any adverse events associated with fluoroquinolone use as reported from January 2004 to December 2008 and obtained from the Adverse Drug Reaction Center, Siriraj Hospital, Thailand, were reviewed.
Among 166,736 patients who had been treated with fluoroquinolones, the prevalences of adverse reaction and cutaneous adverse reaction were 0.13% and 0.09%, respectively. The prevalence of cutaneous reaction to individual fluoroquinolones varies between 0.04% and 0.37%. One hundred fifty-one subjects were enrolled. Most cutaneous reactions were attributed to ciprofloxacin (n = 93), and the most frequent adverse cutaneous reaction seen was maculopapular rash (39.7%). Thirteen cases (8.6%) involved a previous history of fluoroquinolone hypersensitivity; among these, 15.4% had cross-reactivity potential.
These data suggest that individual fluoroquinolones are responsible for different types and frequencies of cutaneous reactions, with some potentiality of cross-reactivity between different generations.
迄今为止，尽管已经有一些关于氟喹诺酮类药物不良反应的大型研究，但仍缺乏专门针对其使用相关皮肤不良反应的综合研究。
展示与氟喹诺酮类药物使用相关的皮肤反应模式，并研究不同类型氟喹诺酮类药物之间的交叉敏感性。
对 2004 年 1 月至 2008 年 12 月期间从泰国诗里拉吉医院药物不良反应中心自愿报告的与氟喹诺酮类药物使用相关的任何不良反应进行回顾性分析。
在 166736 例使用氟喹诺酮类药物的患者中，不良反应和皮肤不良反应的发生率分别为 0.13%和 0.09%。 个体氟喹诺酮类药物引起的皮肤反应发生率在 0.04%至 0.37%之间不等。共纳入 151 例患者。大多数皮肤反应归因于环丙沙星（n = 93），最常见的不良皮肤反应是斑丘疹（39.7%）。有 13 例（8.6%）患者有氟喹诺酮类药物过敏史；其中，15.4%有交叉反应的潜在可能性。
这些数据表明，不同的氟喹诺酮类药物可引起不同类型和频率的皮肤反应，且不同代之间存在一定的交叉反应潜力。
