Department of Otorhinolaryngology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Hear Res. 2011 Oct;280(1-2):58-69. doi: 10.1016/j.heares.2011.04.013. Epub 2011 May 5.
This study investigated the effects of long-term unilateral and bilateral amplification on central auditory processing in elderly people with symmetrical hearing loss using late auditory evoked potentials. It was hypothesized that in the unilateral setting stimulation of the aided ear would yield an acclimatization effect with larger amplitudes and shorter latencies of the components P1, N1 and P2 compared to those of the unaided ear. Auditory evoked potentials were elicited by 500, 1000 and 2000 Hz pure tones at 55, 70 and 85 dB SPL presentation level delivered either to the left or right ear. Unilaterally and bilaterally fitted experienced hearing-aid users and a control group of normally hearing adults, all aged at least 60 years, participated. The responses of the unilateral hearing-aid users did not differ significantly for any of the components P1, N1 or P2 between the aided and unaided ears, but a significant interaction between ear and frequency was present for P2 amplitudes. P2 amplitudes were significantly smaller for the 0.5- and 1-kHz stimuli and tended to be larger for the 2-kHz stimulus in the aided ear suggesting an acclimatization effect. Larger P2 amplitudes were observed in the unilaterally fitted group, which was interpreted as a correlate of more effortful auditory processing in unilaterally fitted people.
本研究采用晚期听觉诱发电位，探讨了长期单侧和双侧放大对听力对称损失老年人中枢听觉处理的影响。研究假设，在单侧设置中，与未助听耳相比，受助耳刺激会产生适应效应，从而使成分 P1、N1 和 P2 的振幅更大，潜伏期更短。500、1000 和 2000 Hz 的纯音以 55、70 和 85 dB SPL 的呈现水平分别刺激左耳或右耳，引出听觉诱发电位。单侧和双侧佩戴有经验的助听器使用者和一个正常听力的成年人对照组都至少 60 岁。单侧助听器使用者的反应在 P1、N1 或 P2 成分中，助听耳和未助听耳之间没有显著差异，但 P2 振幅存在耳和频率之间的显著交互作用。0.5-1 kHz 刺激时 P2 振幅明显较小，2 kHz 刺激时 P2 振幅倾向于较大，提示存在适应效应。在单侧配带组中观察到更大的 P2 振幅，这被解释为单侧配带者更努力进行听觉处理的相关因素。
